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In February, we think about hearts not just in honor of Valentine’s Day but because it is American Heart Association Month. This is a great reminder to focus on our personal cardiovascular health. Renown Health helps patients think about their heart health with our world-class providers and cutting-edge treatments through our Cardiovascular Clinical Trials. “Research serves a vital role in the future care of cardiovascular diseases. Being involved in research will help our medical community to further discover new treatment plans in our quest for life preservation and extension,” Dr. Thomas To, Cardiologist and Researcher at Renown Health. For example, let’s talk about atherosclerosis. When our hearts are healthy, they are a strong muscle that pumps our oxygen-rich blood through our coronary arteries. Over time, cholesterol and fats can build up in our arteries. This is a condition known as atherosclerosis. This type of plaque buildup in the arteries can lead to a heart attack or stroke if not properly managed. If you are experiencing chest pain or discomfort, shortness of breath or pain in areas of the upper body, these can be the warning signs of a heart attack, and you should call 911. One contributing factor to atherosclerosis is elevated lipoprotein(a) levels and the accumulation of cholesterol in the arteries, which increases the likelihood of a heart attack or stroke. Lipoprotein(a) is tested separately from the standard panel that is completed for cholesterol management, and while your total cholesterol levels may be in a healthy range, lipoprotein(a) levels can still be elevated. "Increasingly we are realizing that lipoprotein(a) levels can be used as an important assessment in more carefully delineating an individual's risk of future cardiovascular events and treatment targets" said Dr. Michael Bloch, Lipid Specialist and Researcher at Renown Institute for Heart and Vascular Health. While it is clear that elevated lipoprotein(a) contributes to atherosclerosis, there are currently no approved medications for reducing cardiovascular disease risk through reducing lipoprotein(a) levels. This is why Renown Health’s Research Office is proud to offer a phase III clinical trial, called the OCEAN(a) study, to our patients with elevated lipoprotein(a) levels as a care option for management of their heart disease risk. Our teams of expert providers and researchers are here to support you on your healthcare journey. “I am thrilled to be able to be part of this study and bring opportunities like this to our patients. The highlight of my day is getting to hear life stories from my patients during our study visits,” Lisa Preciado, Primary Clinical Research Coordinator for the OCEAN(a) study said. Join us in raising awareness around American Heart Month by talking to your provider about lipoprotein(a) at your next appointment. At Renown Health, our goal is to make it easy for patients to access clinical research as a care opportunity where patients can access a variety of standard care treatment options for their health condition or choose to participate in a clinical trial. For more information about clinical trial opportunities available to you or to ask any questions, contact the Renown Research Office at Renown-CRD@renown.org or 775-982-3646.

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Stroke is unfortunately common, with 1 in 5 American women experiencing it each year. When it comes to a stroke the phrase “time is brain” speaks to the urgency of getting rapid care. In fact, a woman may lose nearly 2 million neurons per minute of oxygen loss to the brain. The Renown Health Comprehensive Stroke Center experts share the importance of timely treatment and how stroke symptoms can differ in women. Women and Stroke – Surprising Symptoms  Each year stroke affects more women than men. Even more concerning, women are less likely to recover from a stroke. The following non-traditional, less common, warning signs can be common in women: Hiccups with chest pain Sudden disorientation, drowsiness, confusion or a general altered mental status Nausea or vomiting A sudden headache that feels like the ‘worst headache of your life’ Unusual chest pain (especially with hiccups) Body numbness or weakness, such as an arm or leg suddenly ‘falling asleep’ Fainting or loss of consciousness Stroke Diagnosis The first step is neuroimaging by CT scan. This allows for rapid identification of any bleed, and also assists in determining candidacy for the early clot busting medication. MRI brain imaging is much higher resolution, and can better determine the core stroke size, assisting in prognosis and recovery. Since strokes have several different origins, an inpatient workup is essential to determine the underlying cause. Whether the stroke is secondary to plaque in the large vessels, clots being thrown in the setting of atrial fibrillation (an abnormal heart rhythm), or small vessel disease from years of uncontrolled vascular risk factors (high blood pressure, smoking, high cholesterol, diabetes), determining the cause is essential to implementing a management plan to reduce risk for further strokes. Quick Treatment for Stroke is Key Early recognition of stroke symptoms and seeking prompt attention is paramount. There are interventions that can be instituted to minimize the stroke and increase likelihood of recovery, but only if a patient presents to the hospital early. A clot busting medication, called tPA, can be given to patients with stroke if given within 4-5 hours from time of onset. Renown Regional Health Center is designated as a Comprehensive Stroke Center, the highest level of stroke certification available. To earn the designation of comprehensive stroke center, a hospital has to meet stringent requirements, including biannual on-site evaluations. This includes care for ischemic stroke patients (lack of blood flow), hemorrhagic stroke patients (bleeds), and determining the underlying cause to guide secondary stroke management prevention. Stroke Symptoms Remember “B.E.F.A.S.T.” to recognize the symptoms of a stroke below: B – Balance Being off balance or dizzy, is common. E – Eyes An eyesight change such as blurring or double vision may occur. F – Face droop One side of the face, or lip, droops A – Arm weakness Does one arm drift down? S – Speech Talking may slur or sound strange. T – Time Time to call 911. Call an ambulance immediately if you or anyone else, experiences any of these symptoms.

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A mammogram may not be on the top of your to-do list when you turn 40, but it needs to be. The American College of Obstetrics and Gynecology recommends a first mammogram at age 40, however you may need one earlier, so talk with your provider about your breast cancer risk. The purpose of a first time or baseline breast screening, is to get an accurate image of your breasts for future comparisons. Amber Snow, Supervisor of Renown Health Imaging, tells us why it’s important to get a baseline mammogram and what to expect during your visit. Mammogram Screenings Save Lives Simply put, a mammogram is a low-dose x-ray image of your breast from two views: top to bottom and side to side. A yearly screening reduces your risk of dying from breast cancer. Mammograms can detect signs of breast cancer even before you can see or feel it. That’s why it’s important to get a first- time mammogram. About 85% of breast cancers happen to those with no family history of it and in the U.S., one in eight women will develop breast cancer. Unfortunately, the two main risk factors for breast cancer: being female and aging. “Your baseline screening is important when you’re young, so that we know when changes occur,” explains Snow. “We compare your current mammogram to all your previous ones to know if anything changes year to year.” If you are under 40, talk to your provider about getting a formal risk assessment to see if a screening is right for you. If you have a family history of breast cancer a mammogram before age 40 or additional testing may be recommended for you. 3D Mammogram Technology Renown Health uses the latest 3D mammogram technology allowing our radiologists to see early changes in your breast tissue. This also reduces the number of false readings compared to traditional mammograms. While breast screening technology has improved, it is not uncommon to get called back after your first mammogram. According to the American Cancer Society, fewer than 10% of women called back for further testing have been found to have cancer. Reasons for being called back for further imaging include: Dense breast tissue, which can make it hard to see tumors A cyst, mass or unusual tissue is seen A possible area of concern needing another, closer look Preparing for Your Mammogram For an accurate image of your breasts do not wear deodorant, powders or lotions, as they can make it difficult to read your breast images. This is what will happen during your breast screening: A gown will be given to you and you will go to a private area to undress from the waist up, putting on the gown. You will then be escorted to the imaging room and a care team member will place one of your breasts between two plates. The plates will flatten to allow the most breast tissue to be seen and you will feel a firm pressure. You will be asked to hold your breath while the image is taken. An adjustment will be made to the plates to get a side view of the breast. The plate adjustments and images will be done on your other breast. Typically, a mammogram appointment is quick – only lasting about 15 minutes. Be Your Breast Friend While breast screenings are important, it’s also key that you know how your breasts normally look and feel. A monthly self-exam to check for lumps is essential, as breast cancers are often found during a routine self-exam. Remember your hormone levels change monthly, with your breast feeling tender and swollen right before your period. It’s best to perform a breast exam the week after your period after the swelling is gone. To avoid breast tenderness, this is also the best time for a mammogram.

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